2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropyl-purine Off-white solid. PACKAGED UNDER INERT GAS. A potent, cell-permeable, and selective inhibitor of cyclin-dependent kinases (Cdks; IC50 = 4 nM for Cdc2/cyclin B; IC50 = 70 nM for Cdk2/cyclin A; IC50 = 35 nM for Cdk2/cyclin E; and IC50 = 75 nM for Cdk5/p35). Purity: ≥97% by HPLC. CAS 212844-53-6. Ref.: Gray, N.S., et al. 1998. Science 281, 533.
Sold under license of U.S. Patents 6,617,331 and 6,803,371. |
