Ammonium Pyrrolidinedithiocarbamate
APDC
PDTC, NH4 White solid. HYGROSCOPIC. Cell permeable. Inhibits the induction of nitric oxide synthase activity in rat alveolar macrophages. Prevents apoptosis in human HL-60 cells and thymocytes, but induces apoptosis in human and rat smooth muscle cells. Inhibits NF-kB activation and HIV replication in lymphocytes. Purity: ≥98% by titration. CAS 5108-96-3. Ref.: Tsai, J.C., et al. 1996. J. Biol. Chem. 271, 3667. Pan, Z., et al. 1995. J. Biol. Chem. 270, 7787. Bessho, R., et al. 1994. Biochem. Pharmacol. 48, 1883. Sherman, M.P., et al. 1993. Biochem. Biophys. Res. Commun. 191, 1301. Schreck, R., et al. 1992. J. Exp. Med. 175, 1181.
R: 36/37/38; S: 26-36 |
