N-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone Liquid. Supplied as a 10 mM (1 mg/195 µl) solution in DMSO. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A cell-permeable, irreversible, broad-spectrum caspase inhibitor (IC50 = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively) with effective antiapoptotic properties against all major caspase-mediated cellular apoptosis pathways. Exhibits no cytotoxic effects even at extremely high concentrations. Purity: ≥90% by HPLC. Q-Val-Asp-CH2-OPh Ref.: Caserta, T.M., et al. 2003. Apoptosis 8, 345. Rebbaa, A., et al. 2003. Oncogene 22, 2805. |
