3,3′,4′,5,7-Pentahydroxyflavone Yellow solid. PROTECT FROM LIGHT. A cell-permeable inhibitor of PIM1 kinase (IC50 = 43 nM), PI 3-K (IC50 = 3.8 µM) and phospholipase A2 (IC50 = 2 µM). Also inhibits mitochondrial ATPase, phosphodiesterases, and protein kinase C. Induces apoptosis in K562, Molt-4, Raji, and MCAS tumor cell lines. Purity: >98% by HPLC. RTECS LK8950000, CAS 6151-25-3. Merck Index: 14, 8034
Ref.: Bullock, A.N., et al. 2005. J. Med. Chem. 48, 7604. Wei, Y.Q., et al. 1994. Cancer Res. 54, 4952. Shibasaki, F., et al. 1993. Biochem. J. 289, 227. Matter, W.F., et al. 1992. Biochem. Biophys. Res. Comm. 186, 624. Levy, J., et al. 1984. Biochem. Biophys. Res. Commun. 123, 1227. Graziani, Y., et al. 1983. Eur. J. Biochem. 135, 583. Gschwendt, M., et al. 1983. Biochem. Biophys. Res. Commun. 117, 444. Ruckstuhl, M., et al. 1979. Biochem. Pharmacol. 28, 535. Beretz, A., et al. 1978. Experientia 34, 1054.
R: 25-40; S: 36/37/39-45 |
