5-Iodo-3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-2-indolinone
GW 5074 Dark orange solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A potent cRAF1 kinase inhibitor (IC50 = 9 nM). Shows ≥100-fold selectivity for Raf kinase versus Cdk1, Cdk2, c-Src, ERK2, MEK, p38, Tie2, VEGFR2, and c-Fms. Predicted broad spectrum antitumor agents. Purity: ≥97% by HPLC. CAS 220904-83-6. Ref.: Lackey, K., et al. 2000. Bioorg. Med. Chem. Lett. 10, 223. |
