1,6-bis(Cyclohexyloximinocarbonylamino)hexane White to off-white solid. Selective inhibitor of DAG lipase activity in canine platelets (IC50 = 4 nM) and in a variety of mammalian cells. Also inhibits glucose- and carbachol-induced insulin release from intact islets. An inhibitor of Angiotensin II (Cat. No. 05-23-0101) and ATP-induced synthesis of 6-keto-prostaglandin F1a. Purity: ≥98% by TLC. Ref.: Shinoda, J., et al. 1997. Arterioscler. Thromb. Vasc. Biol. 17, 295. Shinoda, J., et al. 1997. Eur. J. Endocrinol. 136, 207. Konrad, R.J., et al. 1994. Biochemistry 33, 13284. Mason-Garcia, M., et al. 1992. Am. J. Physiol. 262, C1197. Balsinde, J., et al. 1991. J. Biol. Chem. 266, 15638. |
