N-(4-Pyridyl)-N′-(2,4,6-trichlorophenyl)urea White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A pyridyl urea compound that acts as a potent, selective, and ATP-competitive inhibitor of Rho-associated protein kinase (ROCK; IC50 = 0.2 µM). Displays little activity towards Erk, PKA, PKC, PDGFR, or c-Kit/SCFR (IC50 > 10 µM). Purity: ≥95% by HPLC. Ref.: Takami, A., et al. 2004. Bioorg. Med. Chem. 12, 2115. |
