3-Hexadecanoyl-5-hydroxymethyl-tetronic Acid Pale yellow solid. PROTECT FROM LIGHT. A specific and noncompetitive inhibitor of protein tyrosine phosphatase with limited cell-permeability. Inhibits dephosphorylation activity of CD45 (IC50 = 54 µM) and VHR (vaccinia H1-related; IC50 = 2 µM) in vitro. Inhibits cell cycle progression of Ball-1 cells at the G1/S transition and enhances ATP-induced long-term potentiation in guinea-pig hippocampal CA1 neurons. Purity: ≥98% by TLC. Ref.: Fujii, S., et al. 1995. Neurosci. Lett. 187, 130. Fujii, S., et al. 1995. Neurosci. Lett. 187, 133. Hamaguchi, T., et al. 1995. FEBS Lett. 372, 54. |
