2-(S)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine White solid. The (S)-enantiomer of the potent cyclin-dependent kinase (Cdk) inhibitor Roscovitine (Cat. No. 557360). Potently inhibits p34cdk1/cyclin B kinase (IC50 = 800 nM). Purity: ≥95% by HPLC. Ref.: Havlicek, L., et al. 1997. J. Med. Chem. 40, 408. Sold under license of U.S. Patent 6,316,456. |