Mallotoxin Orange solid. A cell-permeable protein kinase C inhibitor that exhibits greater selectivity for PKCd (IC50 = 3-6 µM) and PKCq. Inhibits the PKCa, PKCb, and PKCg isoforms, but with significantly reduced potency (IC50 = 30-42 µM). Has reduced inhibitory activity on PKCe, PKCh, and PKCz (IC50 = 80-100 µM). Also known to inhibit CaM kinase III (IC50 = 5.3 µM). Purity: ≥98% by HPLC. RTECS AM6913800, CAS 82-08-6. Merck Index: 14, 8272
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