(m)[(HCO2)(NH3)4Ru]2OCl3 Reddish brown solid. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A cell-permeable oxygen-bridged dinuclear ruthenium amine complex that has been shown to bind to mitochondria with high affinity (Kd = 340 pM). Specifically blocks Ca2+ uptake into mitochondria in vitro (IC50 = 184 pM) and in situ in intact myocytes (complete block after incubation with ~10 µM of Ru360 for 30 min). Does not affect other cellular Ca2+ transport processes involved in cardiac muscle contraction, even at micromolar levels. Purity: ≥97% by capillary electrophoresis. Note: 1 set = 10 x 100 µg. Ref.: Sanchez, J.A., et al. 2001. J. Physiol. 536, 387. Matlib, M.A., et al. 1998. J. Biol. Chem. 273, 10223. Zhou, Z., et al. 1998. J. Physiol. 507 (pt 2), 379. Emerson, J., et al. 1993. J. Am. Chem. Soc. 115, 11799. Ying, W.-L., et al. 1991. Biochemistry 30, 4949. |
