2-[1-3(Aminopropyl)indol-3-yl]-3(1-methyl-1H-indol-3-yl)maleimide, Acetate
Bisindolylmaleimide VIII, Acetate

Red to reddish-orange solid. PROTECT FROM LIGHT. A selective protein kinase C (PKC) inhibitor (IC₅₀ = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC. Does not inhibit the tyrosine phosphorylation or the activation of phospholipase Cg₁. Exhibits some degree of PKC isozyme specificity (IC₅₀ = 53 nM for PKC_a, 195 nM for PKC_bI, 163 nM for PKC_bII, 213 nM for PKC_g, and 175 nM for PKC_e). Inhibits carbachol-evoked noradrenaline release (IC₅₀ = 600 nM). Purity: ≥98% by TLC. CAS 125313-65-7.

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