2-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide, HCl
Bisindolylmaleimide X, HCl Reddish-orange solid. PROTECT FROM LIGHT. A potent and selective protein kinase C inhibitor (IC50 = 15 nM for rat brain PKC). Exhibits some degree of isozyme specificity (IC50 = 8 nM for PKCa, 8 nM for PKCbI, 14 nM for PKCbII, 13 nM for PKCg, and 39 nM for PKCe). Purity: ≥96% by HPLC. CAS 131848-97-0. Ref.: Merritt, J.E., et al. 1997. Cell Signal 9, 53. Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
R: 36/37/38; S: 26-36 |
