3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-y1)-4-(1-methyl-1H-indol-3-y1)-1H-pyrrole-2,5-dione hydrochloride
Bisindolylmaleimide XI, HCl
2-{8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl}-3-(1-methyl-1H-indol-3-yl)maleimide, HCl Red solid. PROTECT FROM LIGHT. A selective cell-permeable protein kinase C inhibitor. Displays about 10-fold greater selectivity for PKCa (IC50 = 9 nM) and 4-fold greater selectivity for PKCbI (IC50 = 28 nM) over PKCe (IC50 = 108 nM). Also prevents T cell-driven chronic inflammatory responses in vivo. Purity: ≥95% by HPLC. CAS 151342-35-7. Ref.: Birchall, A.M., et al. 1994. J. Pharmacol. Exp. Ther. 268, 922. Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335. |
