Lyophilized. Lyophilized from 50 mM NaCl, 10 mM Tris, 1 mM EDTA, 0.1 mM DTT, pH 8.0. S-100 protein purified from bovine brain. A calcium-modulated protein with some structural similarity to calmodulin. Interacts with glial fibrillary acidic protein and inhibits its polymerization in a Ca2+-dependent manner. Originally detected in neural tissue, principally in the cytoplasm of glial cells. Has also been found in chondrocytes, T lymphocytes, and skin. Involved in microtubule dissociation and inhibition of microtubule assembly. Purity: >99% by SDS-PAGE. Ref.: Del Valle, M.E., et al. 1994. Neurosci. Lett. 168, 247. Gallego, M., et al. 1992. Eur. J. Histochem. 36, 205. Katayama, T., et al. 1992. Endocrinol. Jpn. 39, 289. Lackmann, M., et al. 1992. J. Biol. Chem. 267, 7499. Michetti, F., et al. 1992. J. Histochem. Cytochem. 40, 839. Marshak, D., et al. 1983. Proc. Natl. Acad. Sci. USA 78, 6793. Marshak, D.R., et al. 1981. Proc. Natl. Acad. Sci. USA 78, 6793. |
