L-threo-Dihydrosphingosine White solid. A lyso-sphingolipid protein kinase C (PKC) inhibitor that competitively interacts at the regulatory phorbol binding domain of PKC. Inhibits enzymatic activity and 3H-phorbol dibutyrate binding of purified rat brain PKC (IC50 = 37.5 µM and 31 µM, respectively). Inhibits human PKCa, the major overexpressed isoenzyme in MCF-7 DOXR cells (IC50 = 40 µM). Enhances the cytotoxic effect of the chemotherapeutic agent Mitomycin C (MMC; Cat. Nos. 47589 and 475820) in gastric cancer cells by promoting drug-induced apoptosis. Purity: ≥98% by TLC. CAS 15639-50-6. Ref.: Kedderis, L.B., et al. 1995. Fundam. Appl. Toxicol. 25, 201. Sachs, C.W., et al. 1995. J. Biol. Chem. 270, 26639. Schwartz, G.K., et al. 1995. J. Natl. Cancer Inst. 87,1394.
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