Shh Signaling Antagonist V White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A potent, cell-permeable antagonist of the Shh (Sonic Hedgehog) signaling pathway [IC50 = 20 nM in the Shh-LIGHT2 assay and in Ptch1-l- cells] by binding directly to Smoothened (Smo; Kd = 1.2 nM), a distant relative of G protein-coupled receptors. Unlike cyclopamine (Cat. No. 239803), SANT-1 equipotently inhibits the activities of both wild-type and oncogenic Smo (IC50 = 30 nM in SmoA1-LIGHT2 assay). Purity: ≥95% by HPLC. CAS 304909-07-7. Ref.: Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071. Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10. |
