5-(2-Amino-4-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinlyl)imidazole Pale yellow solid. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A potent and specific inhibitor of human p38 MAP Kinase (IC50 = 60 nM). Binds to an extended pocket in the active site of the enzyme. Exhibits over 2000-fold greater selectivity for p38 MAPK over ERK (p42/p44 MAP kinase), 500-fold over PKA, 50-fold over PKC, and >1000-fold over EGFR. Also acts as a potent inhibitor of angiogenesis and as an inhibitor of LPS-induced TNF-a production. Purity: ≥95% by HPLC. CAS 165806-53-1. Ref.: Jackson, J.R., et al. 1998. J. Pharmacol. Exp. Ther. 284, 687. Wang, Z., et al. 1998. Structure 6, 1117. |
