9,10,11,12,-Tetrahydro-9,12-epoxy-1H-diindolo(1,2,3-fg:3′,2′,1′-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-1,3(2H)-dione Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. An indolocarbazole derivative that acts as a potent and selective inhibitor of checkpoint kinase (Chk1) in vitro. It inhibits Chk1 phosphorylation of cdc25C with an IC50 of 15 nM. However, SB-218078 is a much weaker inhibitor of Cdc2 (IC50 = 250 nM) and PKC (IC50 = 1 µM). Purity: ≥90% by HPLC. CAS 135897-06-2. Ref.: Zhao, B., et al. 2002. J. Biol. Chem. 277, 46609. Jackson, J.R., et al. 2000. Cancer Res. 60, 566 |
