Suberic Bishydroxamate
Suberoyl Bishydroxamic Acid White solid. PACKAGED UNDER INERT GAS. A cell-permeable bishydroxamic acid histone deacetylase (HDAC) inhibitor with anti-tumor properties. Causes an increase in acetylated histone H4 in MEL cells and inhibits the human HDAC1 and HDAC3 activities with a similar potency (ID50 ~ 250-300 nM). Belongs to the hybrid polar class of compounds that acts both as inducers of differentiation of transformed cells and apoptosis. Suppresses the growth of proliferating keratinocytes and squamous cell carcinoma cells (IC50 = 11.57 µM and 5.39 µM, respectively). Purity: ≥98% by TLC. CAS 38937-66-5. Ref.: Brinkmann, H., et al. 2001. J. Biol. Chem. 276, 22491. Richon, V.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 3003. Richon, V.M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 5705. Marks, P.A., 1994. Proc. Natl. Acad. Sci. USA 91, 10251.
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