Galloyl-N-gaba-WVDV-OH White powder. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. An N-terminal gallic acid substituted pentapeptide (g-aminobutyric-WVDV) that acts as a specific, high affinity human P-selectin ligand (IC50 = 15.4 nM). Displays weaker affinity towards mouse P-selectin, human L, and E-selectins. Shown to block monocyte-derived HL-60 cell adhesion to P-selectin-transfected CHO cells (EC50 = 74 nM), and reduce the interaction between P-selectin and its endogenous ligand P-selectin glycoprotein ligand-1 (PSGL-1; complete inhibition at 500 nM). Purity: ≥95% by HPLC. Galloyl-N-Gaba-Trp-Val-Asp-Val-OH Ref.: Appeldoorn, C.C.M., et al. 2003. J. Biol. Chem. 278, 10201. |
