5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethylpyrazole Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable, highly potent and selective inhibitor of COX-1 (IC50 = 9 nM). Inhibits COX-2 only at higher concentrations (IC50 = 6.3 µM). Purity: ≥98% by HPLC. CAS 188817-13-2. Ref.: Ostrom, R.S., et al. 2001. Am. J. Physiol. Cell Physiol.281, C524. Smith, C.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 13313. |
