2-Methyl-4-phenyl-5-(4-pyridyl)oxazole White to yellow semi-solid. Potently and selectively inhibits p38 MAP kinase activity in a dose-dependent manner (IC50 = 2-5 µM). Does not inhibit basal ERK or IL-1-induced JNK activity. Purity: ≥98% by HPLC. CAS 318480-82-9. Ref.: Guan, Z., et al. 1998. J. Biol. Chem. 273, 12901. Guan, Z., et al. 1997. J. Biol. Chem. 272, 8083. |