6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide, racemic Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable indole compound that acts as a potent and highly selective inhibitor of SIRT1 (IC50 = 98 nM). It inhibits other sirtuin family deacetylases only at much higher concentrations (IC50 = 19.6 and 48.7 µM for SIRT2 and SIRT3, respectively) and shows no inhibitory effect against class I and II HDACs or NAD glycohydrolase even at concentrations as high as 100 µM. Shown to be orally bioavailable with a serum half-life of 136 minutes in mice in vivo. Purity: ≥95% by HPLC. CAS 49843-98-3. Ref.: Solomon, J.M., et al. 2006. Mol. Cell. Biol. 26, 28. Napper, A.D., et al. 2005. J. Med. Chem. 48, 8045. |
