2-Cyano-3-(5-(2,5-dichlorophenyl)-2-furanyl)-N-5-quinolinyl-2-propenamide
Sirtuin 2 Inhibitor Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable quinoline compound that targets the nicotinamide-binding site and acts as a reversible sirtuin 2- (SIRT2) selective inhibitor (IC50 = 3.5 µM) with little activity against SIRT1/3 (IC50 >50 µM). Prevents cellular a-tubulin deacetylation in HeLa cells in a dose-dependent manner and with little cytotoxic effect. Shown to rescue a-Synuclein-mediated toxicity both in primary rat embryo midbrain cultures in vitro and in a Drosophila PD model in vivo. The inactive isomer AGK7 (Cat. No. 566326) can be used as a negative control. Purity: ≥95% by HPLC. CAS 304896-28-4. Ref.: Outerio, T.F., et al. 2007. Science 317, 516. | 
