6,7-Dimethoxy-2-((2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-prop-2-enoyl))-1,2,3,4-tetrahydroisoquinoline
SIS3
Specific Inhibitor of Smad3 Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable pyrrolopyridine compound that selectively inhibits TGF-b1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling with no effect on Smad2, p38 MAPK, ERK, or PI 3-K signaling. Purity: ≥93% by HPLC. Ref.: Jinnin, M., et al. 2006. Mol. Pharmacol. 69, 597. |
