6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridyl)imidazo[2,1-b]thiazole Off-white solid. PROTECT FROM LIGHT. A bicyclic imidazole cytokine-suppressive, anti-inflammatory drug (CSAID) that inhibits osmotic stress and UV-induced apoptosis by blocking p38 MAP kinase activation as well as lipopolysaccharide (LPS)-stimulated IL-1 and TNF-a production (IC50 = 1 µM) in monocytes. Also acts as an inhibitor of both cyclooxygenases and 5-lipoxygenase, and inhibits osmotic stress. Purity: ≥95% by HPLC. CAS 72873-74-6. Ref.: Frasch, S.C., et al. 1998. J. Biol. Chem. 273, 8389. Blanque, R., et al. 1997. Drugs Exp. Clin. Res. 23, 63. Lee, J.C., et al. 1995. Nature 372, 739. Prichett, W., et al. 1995. J. Inflamm. 45, 97. Lee, J.C., et al. 1993. Ann. N.Y. Acad. Sci. 696, 149.
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