1-[b-[3-(4-Methoxyphenyl)propoxy]-4-methoxyphenethyl]-1H-imidazole, HCl White solid. Inhibits receptor-mediated Ca2+ entry in activated platelets, neutrophils, and endothelial cells at concentrations that do not affect internal Ca2+ release. Also inhibits voltage-gated Ca2+ entry in excitable cells. Inhibits the histamine-induced formation of nitric oxide in human endothelial cells. Purity: ≥98% by TLC. CAS 130495-35-1. Ref.: Leung, Y.-M., et al. 1996. Biochem. Pharmacol. 51, 605. Schwartz, G., et al. 1994. Cell Calcium 15, 45. Cabello, O.A. and Schilling, W.P. 1993. Biochem. J. 295, 357. Graier, W.F., et al. 1992. Biochem. Biophys. Res. Commun. 186, 1539. Blayney, L.M., et al. 1991. Biochem. J. 273, 803. Fasolato, C., et al. 1990. J. Biol. Chem. 265, 20351. Merritt, J.E., et al. 1990. Biochem. J. 271, 515.
R: 36/37/38; S: 26-36 |
