H-AVPIAQK-OH White lyophilized solid. Supplied as a trifluoroacetate salt. PACKAGED UNDER INERT GAS. A peptide that contains the N-terminal seven residues of Smac (Second Mitochondria-derived Activator of Caspases, also known as DIABLO) and promotes procaspase-3 activation at around 10 µM. Reported to bind to the BIR2 and BIR3 (baculovirus IAP repeat) domains of XIAP (X-linked inhibitor of apoptosis proteins) with a Kd ~800 nM. Promotes the catalytic activity of caspase-9 in the presence of XIAP, suggesting that Smac competes with caspase-9 for binding to the same pocket on the surface of XIAP. Purity: ≥95% by HPLC. H-Ala-Val-Pro-Ile-Ala-Gln-Lys-OH Ref.: Srinivasula, S.M., et al. 2001. Nature 410, 112. Chai, J., et al. 2000. Nature 406, 855. Liu, Z., et al. 2000. Nature 408, 1004. Srinivasula, S.M., et al. 2000. J. Biol. Chem. 275, 36152. |
