Butyric Acid, Na NaB White solid. HYGROSCOPIC. A short chain fatty acid that has been shown to induce apoptosis in colon carcinoma cell lines by a p53-independent pathway. Inhibits c-myc splicing and interferes with signal transduction processes, including the release of Ca2+ from intracellular stores. Reduces histamine-induced calcium mobilization in C6 glioma cells. Down-regulates the activity of the serine/threonine protein kinase casein kinase II in HT29 cells. Purity: ≥98% by titration. RTECS ET6400000, CAS 156-54-7. Ref.: Ou, H.C., et al. 1997. Neuroreport 8, 1375. Russo, G.L., et al. 1997. Biochem. Biophys. Res. Commun. 233, 673. Krupitza, G., et al. 1995. Carcinogenesis 16, 1199. Calabresse, C., et al. 1993. Biochem. Biophys. Res. Commun. 195, 31. Hague, A., et al. 1993. Int. J. Cancer 55, 498. R: 20/21/22-36/37/38; S: 26-36 |