Off-white solid. A broad spectrum potent inhibitor of protein tyrosine phosphatases. Also known to inhibit Na+,K+-ATPase, acid and alkaline phosphatases, phosphofructokinase, and adenylate kinase. Also inhibits the ATPase activity of the reconstituted binding protein-dependent ATP-Binding Cassette (ABC) transporter for maltose (MalFGK2) of Salmonella typhimurium in the micromolar range. Can be converted to pervanadate by hydrogen peroxide. RTECS YW1120000, CAS 13721-39-6. Ref.: Huyer, G., et al. 1997. J. Biol. Chem. 272, 843. Hunke, S., et al. 1995. Biochem. Biophys. Res. Commun. 216, 589. Levchuck, S.G., et al. 1994. Pediatric Res. 37, 382A. Fohr, K.J., et al. 1989. Biochem. J. 262, 83. Swarup, G., et al. 1982. Biochem. Biophys. Res. Commun. 107, 1104. Seargeant, L.E. and Stinson, R.A. 1979. Biochem. J. 181, 247.
R: 20/21/22; S: 22-36 |
