NaSal
Salicylic Acid, Na

Off-white solid. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A cell-permeable, non-steroidal anti-inflammatory agent that interferes with TNF-induced NF-kB activation by inhibiting phosphorylation and subsequent degradation of the IkB-a protein. Selectively inhibits TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases. Also inhibits TNF-induced activation of JNK. Induces apoptosis via p38 kinase activation. Inhibits COX-2 and inducible NOS (iNOS) transcription independently of NF-kB activation. Purity: ≥98% by titration. RTECS VO5075000, CAS 54-21-7.

Merck Index: 14, 8332
Ref.: Schwenger, P., et al. 1998. Mol. Cell. Biol. 18, 78. Mitchell, J.A., et al. 1997. Mol. Pharmacol. 51, 907. Schwenger, P., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 2869. Farivar, R.S. and Brecher, P. 1996. J. Biol. Chem. 271, 31585. Schwenger, P., et al. 1996. J. Biol. Chem. 271, 8089.
R: 22; S: 24/25