White solid. Polyamine that plays an important role in the regulation of cellular proliferation and differentiation. Has both stimulatory and inhibitory effects on NMDA receptors depending on the subunit composition of the receptor. Acts as an inhibitor of phospholipase Ca and an activator of phospholipase Cd. Inhibits DNA fragmentation and morphological apoptosis. Inhibits neuronal NOS. Purity: ≥99% by titration. RTECS EJ7230000, CAS 306-67-2.

Merck Index: 14, 8743
Ref.: Igarashi, K. and Williams, K. 1995. J. Pharmacol. Exp. Ther. 272, 1101. Escargueil-Blanc, I., et al. 1994. FASEB J. 8, 1075. Hu, J., et al. 1994. Neurosci. Lett. 175, 41. Tompkins, T.A. and Moscarello, M.A. 1994. Biochim. Biophys. Acta 1206, 1208. Trubiani, O., et al. 1994. Biochem. Mol. Biol. Int. 32, 1085. Svensson, F., et al. 1993. Mol. Cell. Biochem. 124, 141. Ask, A., et al. 1992. Cancer Lett. 66, 29. Chida, N., et al. 1992. Brain Res. 593, 57. Khan, A.U., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 11428. Messena, L., et al. 1992. J. Leukoc. Biol. 52, 585. Pawelczyk, T., et al. 1992. Arch. Biochem. Biophys. 297, 328. Shantz, L.M., et al. 1992. Biochem. J. 288, 511.
R: 36/37/38; S: 26-36