2-(p-Hydroxyanilino)-4-(p-chlorophenyl) thiazole, HCl
SK Inhibitor White solid. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A cell-permeable disubstituted thiazole compound that displays anti-tumor properties. Acts as a potent, non-ATP-competitive, and highly specific inhibitor of sphingosine kinase (IC50 = 0.5 µM for GST-hSK). Does not affect the kinase activity of hERK2, hPI3K, or PKCa even at concentrations as high as 60 µM. Induces apoptosis in human cancer cells that express the drug transport proteins Pgp or MRP1 (IC50 ~ 1-5 µM) through inhibiting sphingosine-1-phosphate production. Purity: ≥98% by HPLC. Ref.: French, K.J., et al. 2003. Cancer Res. 63, 5962. |
