SPC
lyso-Sphingomyelin White solid. PROTECT FROM MOISTURE. SPC is the deacylated derivative of sphingomyelin known to accumulate in neuropathic Niemann-Pick disease type A. A potent mitogen that increases intracellular free Ca2+ and free arachidonate through pathways that are only partially PKC-dependent. Stimulates DNA-binding activity of the transcription activator protein AP-1. Rapidly induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and paxillin and causes a rapid and transient activation of MAP kinase in Swiss/3T3 cells. Also induces a unique reorganization of the actin cytoskeleton. Purity: ≥98% by TLC. CAS 1670-26-4. Ref.: Berger, A., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 5885. Dettbarn, C., et al. 1995. Brain Res. 669, 79. Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24343. Seufferlein, T. and Rozengurt, E. 1995. J. Biol. Chem. 270, 24334. |
