1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one Off-white powder. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable lactone derived from b-naphthol that acts as a selective inhibitor of NAD+-dependent histone deacetylase activity of Sir2 protein (IC50 = 60 µM). It creates a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae and sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket. Purity: ≥95% by HPLC. CAS 5690-03-9. Ref.: Bedalov, A., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 15113. | 
