5-Chloro-3-[(3,5-dimethylpyrrol-2-yl)methylene]-2-indolinone Orange-red solid. PROTECT FROM LIGHT. Potent and selective inhibitor of VEGF (Flk-1; IC50 = 1.2 µM) and PDGF (IC50 = 2.9 µM) receptor tyrosine kinases. Does not have any effect on the EGF and IGF receptor tyrosine kinases. Also inhibits the VEGF-driven mitogenesis of human umbilical vein endothelial cells (HUVECs; IC50 ≤ 680 nM). Inhibits Flt3 phosphorylation in Flt3/Itd-BaF3 cells. Purity: ≥95% by HPLC. Ref.: Cools, J., et al. 2004. Cancer Res. 64, 6385. Sun, L., et al. 1998. J. Med. Chem. 41, 2588.
Not available for sale in the United States. | 
