H-YGRKKRRQR-G-FCDGFYACYKDV-PpYL-OH, Cyclic
P3-AHNP-STAT3BP Lyophilized. Supplied as a trifluoroacetate salt PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. The SH2 domain-binding motif- (Cat. No. 573095) derived STAT3 inhibiting sequence, PpYL (STAT3BP), is conjugated with a cell-permeant carrier sequence P3-AHNP (Cat. No. 573094), to allow its preferential delivery to ErbB2 high-expressing cells for STAT3 inhibition. P3-AHNP-STAT3BP has been shown to selectively inhibit the growth of ErbB2-overexpressing cancer cells both in vitro and in vivo. Purity: ≥97% by HPLC. H2N-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Gly-Phe-Cys-Asp-Gly-Phe-Tyr-Ala-Cys-Tyr-Lys-Asp-Val-Pro-Tyr(PO3H2)-Leu-CO2H, Cyclic Ref.: Tan, M., et al. 2006. Cancer Res. 66, 3764.
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