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| | STAT3 Inhibitor Peptide, Cell-Permeable |
|  | Cat. No. 573096 |
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PpYLKTK-mts White lyophilized solid. Supplied as a trifluoroacetate salt. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A cell-permeable analog of the Stat3-SH2 domain-binding phosphopeptide (Cat. No. 573095) that contains a C-terminal mts (membrane translocating sequence) and acts as a highly selective, potent blocker of Stat3 activation. Also suppresses constitutive Stat-3 dependent Src transformation with no effect on Stat-3 independent Ras transformation. Purity: ≥95% by HPLC. Supplied as a trifluoroacetate salt. H-Pro-Tyr-(PO3H2)-Leu-Lys-Thr-Lys-Ala-Ala-Val-Leu-Leu-Pro-Val-Leu-Leu-Ala-Ala-Pro-OH Ref.: Turkson, J., et al. 2001. J. Biol. Chem. 276, 45443. Rojas, M., et al. 1998. Nat. Biotechnol. 16, 370. |
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EMD Chemicals Inc. USD list price is displayed (pricing with local distributors may vary). NOTE: In Stock status is based on item availability worldwide.
| H2O | C92H157N20O24P | 1958.4 |
| - Rob D. Catalano, et al. (2005) Inhibition of STAT3 activation in the endometrium prevents implantation: a nonsteroidal approach to contraception. Proceedings of the National Academy of Science USA in press,.
- Yoshinari Tanabe, et al. (2005) Role of STAT1, STAT3, and STAT5 in IFN-αβ responses in T lymphocytes. Journal of Immunology 174, 609-613.
- Egle Avizienyte, et al. (2004) Src SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transition. Molecular Biology of the Cell 15, 2794-2803.
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