2-Hydroxy-4-(((4-methylphenyl)sulfonyloxy)acetyl)amino)-benzoic acid
NSC 74859

Light beige solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable amidosalicylic acid compound that binds Stat3-SH2 domain and prevents Stat3 phosphorylation/activation, dimerization, DNA-binding, and Stat3-dependent transcription. Shown to arrest Stat3-dependent tumor growth both in cultures in vitro (effective conc. ≤100 µM) and in a murine xenograft model in vivo (5 mg/kg, i.v.). Purity: ≥95% by HPLC. CAS 501919-59-1.

Ref.: Siddiquee, K., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7391.