5-[4-(2-Pyridylsulfamoyl)phenylazo]salicylic Acid
SSZ

Yellow-orange solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable anti-inflammatory agent that acts as an inhibitor of glutathione-S-transferase (IC₅₀ = 10 µM in HG9 cell line). Strongly inhibits NF-kB activation and potently induces apoptosis in T-lymphocytes. Causes neutrophil apoptosis that can be abrogated by tyrosine kinase inhibitors, protein kinase A inhibitors, or antioxidants. Also inhibits basic fibroblast growth factor-induced endothelial cell chemotaxis. Purity: ≥95%. RTECS VO6250000, CAS 599-79-1.

Merck Index: 14, 8942
Ref.: Liptay, S., et al. 1999. Br. J. Pharmacol. 128, 1361. Volin, M.V., et al. 1999. Arthritis Rheum. 42, 1927. He, N.G., et al. 1998. Toxicol. Appl. Pharmacol. 152, 83. Akahoshi, T., et al. 1997. J. Leukoc. Biol. 62, 817. Awasthi, S., et al. 1994. Br. J. Cancer 70, 190.
R: 42/43-60-63; S: 26-36