(Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic Acid Yellow-orange solid. A cell-permeable, active metabolite of Sulindac (Cat. No. 574100). Strongly inhibits Ras-induced malignant transformation and Ras/Raf-dependent transactivation. Also decreases the Ras-induced activation of c-Raf-1 kinase. Inhibits growth and induces apoptosis in prostate cancer cell lines. Selectively inhibits COX-1 (ID50 = 500 nM) compared to prostaglandin H synthase-2 (PGHS-2; COX-2; ID50 = 14 µM). Preferentially inhibits the secretion of Ab42 in CHO cells stably transfected with both APP75, and the PS1 mutant M146L. Purity: ≥98% by TLC. CAS 32004-67-4. Ref.: Weggen, S., et al. 2001. Nature 414, 212. Lim, J.T., et al. 1999. Biochem. Pharmacol. 58, 1097. Herrmann, C., et al. 1998. Oncogene 17, 1769. Picariello, L., et al. 1998. Eur. J. Pharmacol. 360, 105. Arber, N., et al. 1997. Gastroenterology 113, 1892. Meade, E.A., et al. 1993. J. Biol. Chem. 268, 6610.
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