1-Isothiocyanato-4-(methylsulfinyl)butane
R,S-Sulforaphane

Slight yellow liquid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. An isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture. It has been shown to be an effective agent in prevention of chemically-induced mammary tumors in rats. It also inhibits the phase I cytochrome P450 isoenzymes 2E1 and IA2 which have been associated with the activation of carcinogens. The induction of phase II enzymes is mediated by mitogen-activated protein kinase (MAPK) pathway. Purity: ≥98% by UPLC. CAS 4478-93-7.

Ref.: Gamet-Payrastre, L., et al. 2000. Cancer Res. 60, 1426. Yu, R., et al. 2000. J. Biol. Chem. 275, 2322. Yu, R., et al. 1999. J. Biol. Chem. 274, 27545. Barcelo, S., et al. 1998. Mutat. Res. 402, 111. Maheo, K., et al. 1997. Cancer Res. 57, 3649. Zhang, Y., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3147. Zhang, Y., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 2399.