Colorless oil. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A dimeric dilactone macrolide that is cytotoxic to a variety of cancer cell lines in vitro. Disrupts the actin cytoskeleton by sequestering actin dimers with a binding stoichiometry of 1:1, and rapidly severing F-actin. Also possesses antifungal properties. Purity: ≥98% by HPLC. Ref.: Saito, S.Y., et al. 1998. J. Biochem. (Tokyo) 123, 571. Bubb, M.R., et al. 1995. J. Biol. Chem. 270, 3463. Kobayashi, M., et al. 1994. Chem. Pharm. Bull. 42, 19. Doi, M., et al. 1991. J. Org. Chem. 56, 3629. |
