(4-N,N′-Dimethylanilino)-pentafluorosulfonamide
T1 Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable pentafluorosulfonamide compound that induces microtubule depolymerization and cell-cycle arrest by irreversibly modifying b-tubulin. T113242-induced activation of gene transcriptions has been shown to be mediated by Erk signalling pathway and the transcription factor MIZ-1 (myc-interacting zinc finger protein). Purity: ≥95% by HPLC. Ref.: Ziegelbauer, J., et al. 2004. Proc. Natl. Acad. Sci. USA 101, 458. Ziegelbauer, J., et al. 2001. Mol. Cell 8, 339. |
