N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine Amide
TNF-a Protease Inhibitor-0 White solid. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A hydroxamate-based inhibitor of collagenase, gelatinase, and TACE (TNF-a converting enzyme/ADAM17; IC50 = 100 nM). Blocks spontaneous and PMA-induced release of TNF-a in transfected COS 7 cells. Purity: ≥96% by HPLC. CAS 143457-40-3. Ref.: Hooper, N.M., et al. 1997. Biochem. J. 321, 265. Mullberg, J., et al. 1995. J. Immunol. 155, 5198. Mohler, K.M., et al. 1994. Nature 370, 218.
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