N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine, 2-aminoethyl Amide
TNF-a Protease Inhibitor-1 White solid. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A structural analog of TAPI-0 (Cat. No. 579050) with similar in vitro efficacy for the inhibition of MMPs and TACE (TNF-a converting enzyme/ADAM17). TAPI-1 also blocks the shedding of several cell surface proteins such as IL-6 receptor, p60 TNF receptor, and p80 TNF receptor. Blocks constitutive (IC50 = 8.09 µM) and muscarinic receptor-stimulated (IC50 = 3.61 µM) sAAPa release in HEK 293 cells expressing M3 muscarinic receptors. Purity: ≥97% by HPLC. Ref.: Slack, B.E., et al. 2001. Biochem. J. 357, 787. Vincent, B., et al. 2001. J. Biol. Chem. 276, 37743. Hooper, N.M., et al. 1997. Biochem. J. 321, 265. Crowe, P.D., et al. 1995. J. Exp. Med. 181, 1205. Mullberg, J., et al. 1995. J. Immunol. 155, 5198. Mohler, K.M., et al. 1994. Nature 370, 218.
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