N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-t-butyl-alanyl-L-alanine, 2-aminoethyl Amide
TNF-a Protease Inhibitor-2 White solid. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A hydroxamate-based inhibitor of MMPs and TACE. Inhibits the activation-induced shedding of L-selectin from neutrophils, eosinophils, and lymphocytes, as well as phenylarsine oxide (PAO)-induced shedding in neutrophils. Also acts as a weak inhibitor of angiotensin converting enzyme (IC50 = 18 µM). Purity: ≥97% by HPLC. Ref.: Bennett, T.A., et al. 2000. J. Immunol. 164, 4120. Fiorucci, S., et al. 1998. Aliment. Pharmacol. Ther. 12, 1139. Hooper, N.M., et al. 1997. Biochem. J. 321, 265. Parvathy, S., et al. 1997. Biochem. J. 327, 37. Arribas, J., et al. 1996. J. Biol. Chem. 271, 11376.
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