Lyophilized thin film. PROTECT FROM LIGHT. PROTECT FROM MOISTURE. Mixture of two isomers. Potent inhibitor of protein phosphatases. Inhibits protein phosphatase 1 (IC50 = 1 nM), protein phosphatase 2A (IC50 = 10 nM), and smooth muscle endogenous phosphatase (IC50 = 6 nM). Higher concentrations are needed to inhibit protein phosphatase 2B. Does not inhibit protein phosphatase 2C. Purity: ≥97% by HPLC. RTECS WX1000000, CAS 109946-35-2. Ref.: McCluskey, A., et al. 2002. J. Med. Chem. 45, 1151. Mitsuhashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 287, 328. Kikuchi, K., et al. 1999. Int. J. Mol. Med. 4, 395. Sheppeck, J.E., et al. 1997. J. Org. Chem. 62, 387. Sugiyama, Y., et al. 1996. Bioorg. Med. Chem. Lett. 6, 3. Gong, M.C., et al. 1992. J. Biol. Chem. 267, 14662. Suganuma, M., et al. 1992. Toxicon 30, 873. MacKintosh, C. and Klumpp, S. 1990. FEBS Lett. 277, 137. Magae, J., et al. 1989. J. Antibiot. 42, 1290.
R: 26/27/28; S: 22-36/37/39-45 |
