Baccatin III N-benzyl-b-phenylisoserine Ester
TAXOL® White solid. PROTECT FROM LIGHT. PROTECT FROM MOISTURE. Antitumor and antileukemic agent isolated from the bark of the yew tree. Promotes assembly of microtubules and inhibits tubulin disassembly. An effective agent in blocking HeLa and B16 cells at the G2/M stage. Inhibits DNA synthesis and stimulates the release of tumor necrosis factor-a. Induces apoptosis in murine mammary carcinoma MCA-4 and ovarian carcinoma OCA-1 tumors. Purity: ≥97% by HPLC. RTECS DA8340700, CAS 33069-62-4. Merck Index: 14, 6982
Ref.: Derry, W.B., et al. 1995. Biochemistry 34, 2203. Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297. Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847. Hornback, N.B., et al. 1994. In Vivo 8, 819. Manthey, C.L., et al. 1992. J. Immunol. 149, 2459. Rowinsky, E.K., et al. 1992. Semin. Oncol.19, 646. Ding, A.H., et al. 1990. Science 248, 370. Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101. Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.
R: 37/38-41-46-60; S: 22-26-36/37/39-45 |
